Placenta Makes Antibodies that Bind Up Maternal Antibodies

Peptide Ligands That Bind IgM Antibodies

Antibodies that bind complex glycosaminoglycans accumulate in the Golgi.

Light (L) chains that edit anti-DNA heavy (H) chains rescue B-cell development by suppressing DNA binding. However, exceptional editor L chains allow B cells to reach splenic compartments even though their B-cell receptors remain autoreactive. Such incompletely edited B cells express multireactive antibodies that accumulate in the Golgi and are released as insoluble, amyloid-like immune complex...

Anti-DNA antibodies bind to DNase I

Polyspecificity is a well-known property of the anti-DNA antibodies produced by autoimmune animals. In our search for antigen targets of anti-DNA antibodies within tissue extracts, we identified a 32-kD polypeptide that was recognized by a large panel of anti-DNA antibodies. Direct sequencing of this protein disclosed its identity with DNase I. 22 monoclonal anti-DNA antibodies bound to DNase I...

Permeability of the Human Placenta to Antibodies

The ratio of the titers of various antibodies, namely, hemagglutinins and syphilitic reagin, in the maternal blood to that of the corresponding antibody in the cord blood was found to be relatively constant, falling somewhere between 8 and 16. This figure may be considered the "index of permeability" of human placenta to antibodies, or the coefficient of distribution of antibodies between mater...

Cyclical antiidiotypic response to anti-hormone antibodies due to neutralization by autologous anti-antiidiotype antibodies that bind hormone

Antiidiotype antibodies were raised against anti-catecholamine ligand antibodies. The antiidiotype response was shown to be cyclical and to correspond to the production of antibodies that could bind to catecholamine beta-adrenergic receptors and stimulate adenylate cyclase. Disappearance of these antibodies from the serum could be correlated with the appearance of a catecholamine ligand-binding...